Page 88 - Livre électronique des RFTP 2023

P51.NONSPECIFIC PATTERN OF LUNG FUNCTION

B. BARKOUS, K. KCHAOU, S. JAMLI, C. BRIKI, S. BEN KHAMSA JAMELEDDINE.

DEPARTMENT OF PHYSIOLOGY AND FUNCTIONALRESPIRATORY EXPLORATIONS, ABDERRAHMANE
MAMI HOSPITAL ARIANA, TUNISIA.

INTRODUCTION : Little is known about nonspecific pattern (NSP) of lung function,
which is defined by reduced FEV1 and FVC with a normal FEV1/FVC ratio and
normal total lung capacity (TLC).

OBJECTIVE : To investigate correlations between dyspnea in NSP and different
parameters of lung function tests.
PATIENTS AND METHODS : It was a retrospective study, including 149 patients
diagnosed with NSP, conducted in the department of pulmonary function tests of
Abderrahmane Mami hospital of Ariana. All patients underwent plethysmography
with measurement of FEV1, FVC, TLC, Functional Residual Capacity (FRC), Residual
Volume (RV) and Inspiratory Capacity (IC). Dyspnea was evaluated according to
modified Medical Research Council (mMRC) scale.

RESULTS : From the total sample, 64.9% were females and 46.8% were obese.
Main etiologies of NSP were Sleep Apnea Syndrome (SAS) (27.7%), Interstitial Lung
Disease (ILD) (13.5%), lung cancer (8.1%) and asthma (7.4%). Thirty-three percent of
subjects were smokers and ex-smokers and 23.2% were exposed to wood smoke.
Mean age (years) was 54.52±15.58 and mean BMI (kg/m2) was 30.91±10.53. Dyspnea
was present in 71.9% and was distributed as follows: mMRC 1 (25.9%), mMRC 2
(27.3%), mMRC 3 (15.8%) and mMRC 4 (2.9%). Mean values of FEV1 (%), FVC (%) and
TLC (%) were 62.55±11.37, 64.17±9.41 and 92.92±11.30, respectively. Correlations were
found between dyspnea and FEV1/TLC ratio (r= -0.20, p<0.05), dyspnea and
FEV1/FRC ratio (r= -0.18, p<0.05) and dyspnea with IC (r= 0.25, p<0.05). However,
there were no correlations with FEV1 (%), TLC (%), FRC (%) and FEV1/RV ratio.

CONCLUSION : No recommendations exist actually on how to assess the severity
of NSP. In this study, FEV1/TLC and FEV1/FRC ratios seem to be correlated with
dyspnea.

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