Page 40 - Livre électronique des RFTP 2023

P13. PULMONARY FUNCTION AND LUNG AGEING IN
HEALTHY SMOKERS

C.BRIKI, K.KCHAOU, B.BARKOUS, S.JAMLI, A.BEN AYED,S.BEN KHAMSA JAMELDDINE

DEPARTMENT OF PHYSIOLOGY AND FUNCTIONALRESPIRATORY EXPLORATIONS, ABDERRAHMEN
MAMI HOSPITAL, ARIANA, TUNISIA.

INTRODUCTION : Cigarette smoking is the leading cause of preventable death
worldwide. It causes Chronic Obstructive Pulmonary Disease (COPD) and
progressive decline in lung function. In this context, healthy smokers are not spared
from functional pulmonary abnormalities.

OBJECTIVE : To characterize clinical and functional profiles in healthy smokers.

METHODS : It was a retrospective study conducted in the functional respiratory
exploration department of Abderrahman MAMI hospital of Arianna from 2016 to
2020.Data of demographic characteristics (age, ethnicity, BMI) were recorded for
all subjects. Clinical data including Tobacco Consumption (TC), modified Medical
Research Council Scale (mMRC) and patient medical history were completed.
Spirometry was performed with measurement of Forced Expiratory Volume in one
second (FEV1), Forced Vital Capacity (FVC) and Peak Expiratory Flow (PEF).
Estimated Lung Age (ELA) was calculated according to this formula (QUANJER et
al): (1.483 * height) - (34.483*FEV1) -85.8621. Lung Ageing (LA) was retained when
measured lung age was higher than chronological age.

RESULTS : The study population included 666 patients. Means of age (years), BMI
(kg/m2) and TC (pack/year) were 52.55±8.64, 26.48±5.23 and 37.44 ± 26.78,
respectively. Fifty six percent of study population had mMRC ≥1 of which 0.5 % had
mMRC =4. Spirometric measurement showed that means of FEV1, FVC and PEF
were 95.18±12.11, 95.66 ±13.23 and 87.59±17.92. As for the LA, it was present in 68.2%
(n=454) and mean ELA (years) was 58.04±17.36.
CONCLUSION : Despite the absence of airflow limitation in baseline spirometry,
our study confirms that smokers do suffer from dyspnea and LA.

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