Page 147 - Livre électronique des RFTP 2023

P95.CLINICAL, SPIROMETRIC AND THERAPEUTIC PROFIL
OF FREQUENT EXACERBATORS IN COPD

W. BENZARTI, F.DABBEBI, A.KNAZ, B.BENBDIRA, I.GARGOURI, O.TABKA, S.AISSA,
A.ABELGHANI

SERVICE DE PNEUMOLOGIE CHU FARHAT HACHED DE SOUSSE, TUNISIE

INTRODUCTION : Chronic obstructive pulmonary disease (COPD) is a frequent yet
underestimated chronic inflammatory disease. It is a major public health problem
due to its high morbidity and mortality. Acute exacerbation (AE) of COPD is a fatal
event, leading to poor outcomes among COPD patients frequent exacerbator.

This study aimed to describe the frequent exacerbator phenotype in patients with
COPD.

METHODS: This is a retrospective descriptive study of patients who had presented
at least two COPD AEs during one year of follow-up; in the Pneumology
Department at Farhat Hached Hospital of Sousse, Tunisia.

RESULTS: A total of277 patients were enrolled in this study The mean age was 67
years with extremes ranging from 41 to 89 years, and 87.7% of the patients male ;
43.6 % of the patients were current smokers and 46.5% were ex-smokers.44% had at
least one comorbidity associated with COPD. Dyspnea was the major symptom;
patients were classified as stage 2 and 3 respectively in 41.2% and 43.7% of cases.
NAs for the frequency of AE per patients per year was 2, 94 with extremes ranging
from 2 to 10 ; and 74% of the patients had presented at least one COPD AE requiring
hospitalization.

The mean FEV1 was 1,115 ml (41.63%) pre-bronchodilation and 1,221 ml (42.59%)
post-bronchodilation and the subjects were classified as follows: GOLD 1 (7.2%),
GOLD 2 (19.9%), GOLD 3 (41.5%), GOLD 4 (31 ,4%).
It was noted that 24.5% of our frequent exacerbators were on ICS while 7.9% were
on a double long-acting bronchodilator and only 9.4% were on inhaled triple
therapy.

CONCLUSION : The frequent exacerbator phenotype among patients with COPD
is a particular entity, with distinct characteristics, requiring standardized
management.

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